From “Reduction First, Then Acylation” to “Direct Amidation”: An Unconventional Route to Amide Bond Formation from Nitro and Nitroso Substrates with α-Keto Carboxylic Acids

The most familiar route from nitro compounds to amides is usually to first reduce the nitro group to an amine, and then react that amine with a carboxylic acid derivative or an activated carboxylic acid system. This route is mature, reliable, and remains the most common choice in both laboratory ...