The most familiar route from nitro compounds to amides is usually to first reduce the nitro group to an amine, and then react that amine with a carboxylic acid derivative or an activated carboxylic acid system. This route is mature, reliable, and remains the most common choice in both laboratory ...
Amide bond formation is one of the most common fundamental transformations in the synthesis of drug molecules, natural products, and functional molecules. In efforts to improve amidation reactions, researchers are concerned not only with whether a bond can be formed, but also with whether the ...
Amide bond formation is one of the most common fundamental transformations in organic synthesis, medicinal chemistry, and the preparation of functional molecules. In efforts to improve amidation reactions, the central questions have remained the same: can additional activation steps be reduced, ...
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