Gentamicin is an aminoglycoside antibiotic used in antibacterial therapy and cell culture contamination control. Because it can induce oxidative stress, mitochondrial dysfunction, lysosomal abnormalities, apoptosis, and necrosis-like injury, gentamicin is often used to construct injury models in ...
Oxidative stress and mitochondrial dysfunction are not two independent events, but rather a continuous process driven by the mutual reinforcement of reactive oxygen species accumulation, membrane-potential fluctuation, mitochondrial permeability transition pore opening, and calcium-homeostasis ...
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