Glucose-6-phosphate dehydrogenase (G6PD) is the key rate-limiting enzyme of the oxidative phase of the pentose phosphate pathway (PPP). It catalyzes the oxidation of glucose-6-phosphate (G6P) to 6-phosphoglucono-δ-lactone while reducing NADP⁺ to NADPH. NADPH is pivotal for antioxidant ...
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