Sunitinib Malate - ≥99% , Tyrosine-protein kinase receptor RET inhibitor, CAS No.341031-54-7, Tyrosine-protein kinase receptor RET inhibitor

CAS: 341031-54-7 Cat. No.: E129728 Molecular Weight: 532.56 EC Number: 638-825-9

GRADE & PURITY ≥99%

Synonyms

1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1) | CAS-341031-54-7 | Sunitinib malate | (Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Specifications

Synonyms

1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1, 2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2, 4-dimethyl-, (2S)-hydroxybutanedioate (1:1) | CAS-341031-54-7 | Sunitinib malate | (Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindo

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Potent, ATP-competitive VEGFR, PDGFRβand KIT inhibitor (Kivalues are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβand KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor a

Legal Information

Sold for only research purposes

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Tyrosine-protein kinase receptor RET inhibitor

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504764241
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764241
• Canonical Smiles: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
• IUPAC Name: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid
• InChIKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N
• INCHI: 1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
• Isomeric SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
• WGK Germany: 2
• Molecular Weight: 532.56
• Reaxy-Rn: 14643863
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14643863&ln=

Associated Targets(Human)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (1 Activities)

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSF1R Tclin Macrophage colony stimulating factor receptor (5179 Activities)

Discover Target: CSF1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

NIH3T3 (5395 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 13.31, Max Conc. mM: 25
• Molecular Weight: 532.600 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 532.233 Da
• Monoisotopic Mass: 532.233 Da
• Topological Polar Surface Area: 172.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 765.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 2

XLogP3