VEGFR Inhibitors

Vascular endothelial growth factor receptor (VEGFR) inhibitors are a class of compounds that block signaling through VEGF receptor tyrosine kinases. VEGFR plays a central role in angiogenesis, the formation of new blood vessels, which is a critical process in tumor growth and progression. By mediating recruitment of circulating endothelial precursor cells and supporting the survival of immature tumor-associated vasculature, VEGFR signaling sustains the blood supply that tumors require for continued growth. Inhibition of this pathway prevents vessel development and downstream activation, thereby suppressing angiogenesis and limiting tumor expansion.

Representative VEGFR inhibitors from Aladdin are listed in the blow sheet

Aladdin catalog	Product name	Purity
A126970  T407804	17-AAG	≥98%, 10mM in DMSO
A412643	Arenobufagin	≥98%
A129732 A408268	Axitinib	≥99%, 10mM in DMSO
B126145  A408856	AC480 (BMS-599626)	≥98% 10mM in DMSO
C126195  C408733	Cabozantinib	≥98%, 10mM in DMSO
C125911  C408684	Cediranib	≥98%  10mM in DMSO
F127011  F407825	Foretinib	≥98%  10mM in DMSO
I111283  I111284  I407952	Isoliquiritigenin	analytical standard ≥98% 10mM in DMSO
M126795 M424063	Motesanib	≥98% 10mM in DMSO
N127928  N408613	NVP-BHG712	≥98%, 10mM in DMSO
P125184  P424022	Pazopanib	≥99%, 10mM in DMSO
P126419  P408944	PP121	≥98% 10mM in DMSO
R127906  R409224	RAF265	≥98%  10mM in DMSO
R413223  R420361	Regorafenib (BAY-734506) Monohydrate	≥99% 10mM in DMSO
S413502  S420654	SKLB 610	≥98% 10mM in DMSO
S125098 S408543	Sorafenib	≥99% 10mM in DMSO
S167823  S422089	SU1498	≥98%  10mM in DMSO
E129728  S408002	Sunitinib Malate	≥99% 10mM in DMSO
T126012 T409225	Tivozanib (AV-951)	≥98% 10mM in DMSO
V125180 V407820	Vandetanib	≥99% 2mM in DMSO
V125857  V408583	Vatalanib (PTK787) 2HCl	≥99% 10mM in DMSO

References:

1. Moriera IS, Fernandes PA, Ramos MJ. Anticancer Agents Med Chem. 2007 Mar;7(2):223-45.

Aladdin: https://www.aladdinsci.com/