Peptide Intermediates Difficult to Dissolve and Separate? Route Design and Workup Strategies for Tag-Assisted Liquid-Phase Peptide Synthesis (TAG-LPPS)

The challenges in peptide synthesis often lie not only in whether peptide bonds can be formed, but also in whether the intermediates after each reaction step can dissolve, be separated, and continue to undergo subsequent transformations. For some peptides with high hydrophobicity, long ...