How to Map the NF-κB Pathway and Choose Inhibitors: Bringing Inflammatory Transcriptional Output into a “Controllable Range” (Tables A–F)

In settings such as inflammation, autoimmunity, infection, and the tumor microenvironment, researchers often encounter the same phenomenon: for example, blocking a single cytokine or inhibiting a single receptor may initially drive biomarkers down and look effective. But after a while, ...