Fluoropyridines can be divided into three positional isomers: ortho, meta, and para. For synthetic chemistry, these three isomers do not present the same level of difficulty. Ortho- and para-fluoropyridines can usually be obtained through well-established halogen-exchange reactions, commonly ...
In drug design, halogen bond interactions are often applied, but their conformation is mainly limited to the aromatic plane. Recently, Professor Franziska Zimmermann's team at the University of Tübingen in Germany published a paper in the journal J. Med. Chem., introducing the unique advantages ...
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