Topic: Functional Group

Articles by Topic "Functional Group"

Knowledge Base
Technical articles

Formation and Control of Carboxyl- and Hydroxyl-Related Impurities in Peptide Synthesis — Using Asp/Glu and Ser/Thr Residue Side Reactions as Examples

In peptide synthesis, impurities do not always originate from “incomplete coupling” or “incomplete deprotection.” Many quality issues arise because certain functional groups enter undesired reaction pathways under specific conditions. Carboxyl and hydroxyl groups are two typical ...

Updated Jul 20268 min read ✓ Reviewed
Technical articles

Selection Logic for the Teoc Amino Protecting Group: From Fluoride-Triggered Deprotection to Orthogonal Protecting-Group Design

Teoc [2-(trimethylsilyl)ethoxycarbonyl] is one of the commonly used silyl carbamate protecting groups for amines. Its distinctive feature is that it can be removed under fluoride-triggered conditions, and it is therefore often used in multistep synthesis as an alternative to the more common ...

Updated Apr 20268 min read ✓ Reviewed
Technical articles

How to Construct Nitriles: Route Selection Across Direct Introduction, Precursor Dehydration, Oxidation/Dehydrogenation, and Cyanide-Free Processes

The nitrile group is a common functional group in medicinal chemistry, agrochemical chemistry, fine chemicals, and functional molecules, and it is also a highly useful synthetic intermediate. It can exist directly as a structural unit within a molecule, and it can also be readily transformed ...

Updated Apr 20268 min read ✓ Reviewed
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