Experimental Assessment of Fmoc Introduction Routes: Impurity Profile Differences, Raw Material Carryover, and Quality Control

In the preparation of peptides and amino acid derivatives, the Fmoc (9-fluorenylmethoxycarbonyl) protection strategy is already highly mature. Merrifield established the basic framework of solid-phase peptide synthesis (SPPS), and Carpino subsequently introduced the Fmoc protecting group, which ...