TCFH [N,N,N′,N,N′-tetramethylchloroformamidinium hexafluorophosphate] is often simply classified as a “powerful coupling reagent,” but a more accurate description is that it is a carboxylic acid activation reagent capable of directing carboxylic acids into different highly reactive ...
tert-Butyl esters are among the most commonly used protecting groups for carboxylic acids. Their long-standing importance mainly rests on two features: first, they show good stability toward a variety of nucleophiles and reducing conditions; second, they can be removed relatively conveniently ...
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