Experimental Selection Logic for Transition-Metal-Catalyzed C–H Functionalization: When It Is Worth Pursuing and How to Assess Site Selectivity and Conditions

This article focuses on carbon-hydrogen (C–H) functionalization within the framework of transition-metal catalysis, and does not cover other types of C–H transformations such as radical, photoredox, or electrochemical processes. The central questions addressed here are: how to judge whether ...