DMAP Is More Than Just an Organic Base: Experimental Judgment from Nucleophilic Acyl Transfer to Esterification and Macrolactonization

The importance of 4-dimethylaminopyridine (DMAP, 4-dimethylaminopyridine) in organic synthesis lies primarily in its ability to significantly promote acyl transfer. DMAP can first react with an activated acyl donor to form a more reactive acyl pyridinium intermediate, and then transfer the acyl ...