RS 102895 - 98%, high purity , CAS No.300815-41-2, Antagonist of CCR2

Item Number

R335959

Grouped product items
SKU	Size	Availability	Price
R335959-1mg	1mg	5	$20.90
R335959-5mg	5mg	3	$77.90
R335959-10mg	10mg	2	$118.90
R335959-25mg	25mg	1	$267.90
R335959-50mg	50mg	1	$470.90
R335959-100mg	100mg	1	$846.90

a CCR2-selective chemokine receptor antagonist

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Basic Description

Synonyms	1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one HCl \| AKOS024456940 \| 1'-{2-[4-(Trifluoromethyl)phenyl]ethyl}spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one--hydrogen chloride (1/1) \| BCP18408 \| RS-102895 HCl \| 1
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR2
Product Description	RS 102895 Hydrochloride is a CKR-2B (CCR2)-selective chemokine receptor antagonist (IC\|50\|values are 0.36 and 17.8 μM for inhibition of human recombinant CKR-2B and CKR-1 (CCR2b and CCR1 receptors) respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC\|50\|values of 32 nM and 1.7 μM respectively. Inhibits α\|1A\|-AR, α\|1D\|-AR and SR-1A (α1A, α1D and 5-HT\|1A\|receptors).

Names and Identifiers

IUPAC Name	1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride
INCHI	InChI=1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChi Key	KRRISOFSWVKYBF-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
Isomeric SMILES	C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
WGK Germany	3
PubChem CID	16759153
Molecular Weight	390.40

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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12 results found

Lot Number	Certificate Type	Date	Item
F2309922	Certificate of Analysis	May 10, 2023	R335959
F2310469	Certificate of Analysis	May 10, 2023	R335959
F2310473	Certificate of Analysis	May 10, 2023	R335959
F2310475	Certificate of Analysis	May 10, 2023	R335959
F2310477	Certificate of Analysis	May 10, 2023	R335959
F2310479	Certificate of Analysis	May 10, 2023	R335959
F2310481	Certificate of Analysis	May 10, 2023	R335959
F2310485	Certificate of Analysis	May 10, 2023	R335959
F2310486	Certificate of Analysis	May 10, 2023	R335959
F2310488	Certificate of Analysis	May 10, 2023	R335959
F2310493	Certificate of Analysis	May 10, 2023	R335959
F2310495	Certificate of Analysis	May 10, 2023	R335959

References

1. Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, Mulkins M, Weatherhead GS, Lapierre JM, Dankwardt J et al.. (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.. J Biol Chem, 275 (33): (25562-71). [PMID:10770925] [10.1021/op500134e]
2. Clark RD, Caroon JM, Kluge AF, Repke DB, Roszkowski AP, Strosberg AM, Baker S, Bitter SM, Okada MD. (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.. J Med Chem, 26 (5): (657-61). [PMID:6842505] [10.1021/op500134e]

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Basic Description