| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| R274707-5mg | 5mg | 2 | $79.90 | |
| R274707-10mg | 10mg | 2 | $127.90 | |
| R274707-25mg | 25mg | 2 | $288.90 | |
| R274707-50mg | 50mg | 2 | $495.90 | |
| R274707-100mg | 100mg | 2 | $892.90 |
Selective CCR2 receptor antagonist
| Synonyms | 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one HCl | AKOS024456940 | 1'-{2-[4-(Trifluoromethyl)phenyl]ethyl}spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one--hydrogen chloride (1/1) | BCP18408 | RS-102895 HCl | 1 |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Selective CCR2 receptor antagonist (IC 50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC 50 values are 32 and 130 nM, respectively). Active in vivo . |
| Storage Temp | Store at -20°C,Argon charged,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504768521 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504768521 |
| IUPAC Name | 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride |
| INCHI | InChI=1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H |
| InChi Key | KRRISOFSWVKYBF-UHFFFAOYSA-N |
| Canonical SMILES | C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl |
| Isomeric SMILES | C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl |
| PubChem CID | 16759153 |
| Molecular Weight | 426.9 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C23021029 | Certificate of Analysis | Dec 20, 2023 | R274707 |
| C23021033 | Certificate of Analysis | Dec 20, 2023 | R274707 |
| C23021186 | Certificate of Analysis | Dec 20, 2023 | R274707 |
| C23021187 | Certificate of Analysis | Dec 20, 2023 | R274707 |
| C23021192 | Certificate of Analysis | Dec 20, 2023 | R274707 |
Starting at $241.90
| 1. Wang JB et al.. (2022) CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.. Cancer Gene Ther, [PMID:35999359] |
| 2. Han S et al.. (2019) High CCL7 expression is associated with migration, invasion and bone metastasis of non-small cell lung cancer cells.. Am J Transl Res, 11 (442-452). [PMID:30788000] |
| 3. Zhan X et al.. (2020) Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration.. BMC Dev Biol, 20 (20). [PMID:33023470] |
| 4. Maolake A et al.. (2017) Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis.. Oncotarget, 8 (6): (9739-9751). [PMID:28039457] |
