Grouped product items

SKU

Size

Availability

Price

Qty

R129674-10mg

10mg

Available within 4-8 weeks(?)

$53.90

R129674-50mg

50mg

Available within 4-8 weeks(?)

$75.90

R129674-250mg

250mg

$342.90

R129674-1g

$1,231.90

Basic Description

Synonyms	BDBM14361 \| BRN 1588548 \| Tox21_110672 \| KBio2_000076 \| MLS000759531 \| Opera_ID_1749 \| BCP23388 \| KBio2_005212 \| SR-01000000162 \| GTPL5260 \| HMS1791D18 \| KBio2_002644 \| KS-1400 \| Pharmakon1600-01505683 \| Rolipramum \| SMR000058510 \| BPBio1_000912 \| HMS2097
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile re
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphodiesterase 4A;Inhibitor of phosphodiesterase 4B;Inhibitor of phosphodiesterase 4C;Inhibitor of phosphodiesterase 4D
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors. A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).

AI Insight

Product Properties

ALogP	2.2

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504750844
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504750844
IUPAC Name	4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
INCHI	InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChi Key	HJORMJIFDVBMOB-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
Isomeric SMILES	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
WGK Germany	3
RTECS	UY5749237
Alternate CAS	61413-54-5
PubChem CID	5092
NSC Number	760125
MeSH Entry Terms	Rolipram;ZK 62711;ZK-62711;ZK62711
Molecular Weight	275.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
A2305734	Certificate of Analysis	Oct 17, 2024	R129674
A2305711	Certificate of Analysis	Oct 17, 2024	R129674
A2305712	Certificate of Analysis	Oct 10, 2024	R129674
A2305735	Certificate of Analysis	Oct 10, 2024	R129674
K1814186	Certificate of Analysis	Apr 07, 2024	R129674
F1502084	Certificate of Analysis	Jan 25, 2023	R129674
K1814185	Certificate of Analysis	Jul 18, 2022	R129674

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	UY5749237
Merck Index	8251

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Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Youzhi Wang, Huifang Wang, Guoqing Yang, Qingjing Hao, Kan Yang, Huizhen Shen, Yulong Wang, Jinxin Wang. (2023) Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 256 (115374). [PMID:37150057] [10.1016/j.ejmech.2023.115374]
2. You-Zhi Wang, Yu-Long Wang, Hao-Jie Che, Yi-He Jia, Hui-Fang Wang, Lin-Fei Zuo, Kan Yang, Ting-Ting Li, Jin-Xin Wang. (2023) Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.. JOURNAL OF ETHNOPHARMACOLOGY, 304 (116020). [PMID:36529254] [10.1016/j.jep.2022.116020]
3. Zhuo-Er Qiu, Lei Chen, Xiao-Chun Hou, Jie Sheng, Jian-Bang Xu, Jia-Wen Xu, Dong-Dong Gao, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Lei Peng, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Wei-Jie Guan, Zhao-Rong Lun, Wen-Liang Zhou, Yi-Lin Zhang. (2023) Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl− concentration in airway epithelium. JOURNAL OF INFECTION, 86 (47). [PMID:36334726] [10.1016/j.jinf.2022.10.037]
4. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin. (2020) Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation. EUROPEAN JOURNAL OF PHARMACOLOGY, 872 (172951). [PMID:32006560] [10.1016/j.ejphar.2020.172951]

References

1. Huang Z, Mancini JA. (2006) Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.. Curr Med Chem, 13 (27): (3253-62). [PMID:17168849] [10.1021/op500134e]
2. Normann C, Berger M. (2008) Neuroenhancement: status quo and perspectives.. Eur Arch Psychiatry Clin Neurosci, 258 Suppl 5 (13): (110-4). [PMID:18985306] [10.1021/op500134e]
3. García-Osta A, Cuadrado-Tejedor M, García-Barroso C, Oyarzábal J, Franco R. (2012) Phosphodiesterases as therapeutic targets for Alzheimer's disease.. ACS Chem Neurosci, 3 (11): (832-44). [PMID:23173065] [10.1021/op500134e]
4. Kumar N, Goldminz AM, Kim N, Gottlieb AB. (2013) Phosphodiesterase 4-targeted treatments for autoimmune diseases.. BMC Med, 11 (13): (96). [PMID:23557064] [10.1021/op500134e]
5. Ahmad F et al.. (2021) Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration.. Cells, 10 (5): [PMID:34065927]
6. Severino J et al.. (2022) Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.. EMBO J, 41 (12): (e109457). [PMID:35603814]
7. Shelly M et al.. (2010) Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation.. Science, 327 (5965): (547-52). [PMID:20110498]
8. Murase Y et al.. (2020) Long-term expansion with germline potential of human primordial germ cell-like cells in\xa0vitro.. EMBO J, 39 (21): (e104929). [PMID:32954504]
9. Nelissen E et al.. (2021) Soluble Guanylate Cyclase Stimulator Vericiguat Enhances Long-Term Memory in Rats without Altering Cerebral Blood Volume.. Biomedicines, 9 (8): [PMID:34440254]
10. Nelissen E et al.. (2022) The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.. Sci Rep, 12 (3589). [PMID:35246566]
11. Youzhi Wang, Huifang Wang, Guoqing Yang, Qingjing Hao, Kan Yang, Huizhen Shen, Yulong Wang, Jinxin Wang. (2023) Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 256 (115374). [PMID:37150057] [10.1016/j.ejmech.2023.115374]
12. You-Zhi Wang, Yu-Long Wang, Hao-Jie Che, Yi-He Jia, Hui-Fang Wang, Lin-Fei Zuo, Kan Yang, Ting-Ting Li, Jin-Xin Wang. (2023) Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.. JOURNAL OF ETHNOPHARMACOLOGY, 304 (116020). [PMID:36529254] [10.1016/j.jep.2022.116020]
13. Zhuo-Er Qiu, Lei Chen, Xiao-Chun Hou, Jie Sheng, Jian-Bang Xu, Jia-Wen Xu, Dong-Dong Gao, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Lei Peng, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Wei-Jie Guan, Zhao-Rong Lun, Wen-Liang Zhou, Yi-Lin Zhang. (2023) Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl− concentration in airway epithelium. JOURNAL OF INFECTION, 86 (47). [PMID:36334726] [10.1016/j.jinf.2022.10.037]
14. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin. (2020) Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation. EUROPEAN JOURNAL OF PHARMACOLOGY, 872 (172951). [PMID:32006560] [10.1016/j.ejphar.2020.172951]

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Rolipram - ≥97%, high purity , CAS No.61413-54-5, Inhibitor of phosphodiesterase 4A;Inhibitor of phosphodiesterase 4B;Inhibitor of phosphodiesterase 4C;Inhibitor of phosphodiesterase 4D