AKOS025310621 | (E)-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-beta-methyl-2H-pyran-2-crotonic acid, ester with 9-hydroxynonanoic acid | (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]te
Specifications & Purity
Moligand™, ≥95%
Biochemical and Physiological Mechanisms
Narrow spectrum antibiotic agent. Binds to isoleucyl t-RNA synthetase and inhibits protein synthesis. Shows dose dependent bacteriostatic and bactericidal effects against Gram-positive bacteria in vivo.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Isoleucyl-tRNA synthetase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Describtion:
Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid. An antibiotic inhibitor of isoleucyl-tRNA synthetase
Product Application：
Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
2.Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao. (2023) Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. Materials Today Bio, 18 (100534). [PMID:36686036][10.1016/j.mtbio.2022.100534]
3.Haohua Liu, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun. (2022) Formulation of Chrysomycin A Cream for the Treatment of Skin Infections. MOLECULES, 27 (14):(4613). [PMID:35889485][10.3390/molecules27144613]
4.Li Jun, Liu Xiangmei, Tan Lei, Cui Zhenduo, Yang Xianjin, Liang Yanqin, Li Zhaoyang, Zhu Shengli, Zheng Yufeng, Yeung Kelvin Wai Kwok, Wang Xianbao, Wu Shuilin. (2019) Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds. Nature Communications, 10 (1):(1-15). [PMID:31582736][10.1038/s41467-019-12429-6]
References
1.Hurdle JG, Yendapally R, Sun D, Lee RE. (2009) Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.. Antimicrob Agents Chemother, 53 (9):(4028-31). [PMID:19581456][10.1021/op500134e]
2.Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. (2011) Validation of isoleucine utilization targets in Plasmodium falciparum.. Proc Natl Acad Sci U S A, 108 (4):(1627-32). [PMID:21205898][10.1021/op500134e]
4.Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao. (2023) Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. Materials Today Bio, 18 (100534). [PMID:36686036][10.1016/j.mtbio.2022.100534]
5.Haohua Liu, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun. (2022) Formulation of Chrysomycin A Cream for the Treatment of Skin Infections. MOLECULES, 27 (14):(4613). [PMID:35889485][10.3390/molecules27144613]
6.Li Jun, Liu Xiangmei, Tan Lei, Cui Zhenduo, Yang Xianjin, Liang Yanqin, Li Zhaoyang, Zhu Shengli, Zheng Yufeng, Yeung Kelvin Wai Kwok, Wang Xianbao, Wu Shuilin. (2019) Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds. Nature Communications, 10 (1):(1-15). [PMID:31582736][10.1038/s41467-019-12429-6]
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E2410010
