| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M421107-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 |
Narrow spectrum antibiotic agent
| Synonyms | Mupirocin | 12650-69-0 | Pseudomonic acid | Bactroban | Mupirocine | Centany | Pseudomonic acid A | Bactoderm | Mupirocina | Mupirocinum | Turixin | BRL 4910A | BRL-4910A | trans-Pseudomonic acid | 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxir |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Narrow spectrum antibiotic agent. Binds to isoleucyl t-RNA synthetase and inhibits protein synthesis. Shows dose dependent bacteriostatic and bactericidal effects against Gram-positive bacteria in vivo. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Isoleucyl-tRNA synthetase inhibitor |
| Product Description | Product Describtion: Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid. Product Application： Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid. |
| ALogP | 3 |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid |
|---|---|
| INCHI | InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1 |
| InChi Key | MINDHVHHQZYEEK-HBBNESRFSA-N |
| Canonical SMILES | CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O |
| Isomeric SMILES | C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O |
| WGK Germany | 2 |
| RTECS | RA6907000 |
| PubChem CID | 446596 |
| Molecular Weight | 500.62 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
| WGK Germany | 2 |
| RTECS | RA6907000 |
| Merck Index | 6302 |
| 1. Yupeng Shi, Mengyang Zhou, Shuo Zhao, Haotian Li, Wenhao Wang, Jingliang Cheng, Lin Jin, Yifei Wang. (2023) Janus amphiphilic nanofiber membranes synergistically drive antibacterial and anti-inflammatory strategies for skin wound healing. MATERIALS & DESIGN, 227 (111778). [PMID:] [10.1016/j.matdes.2023.111778] |
| 2. Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao. (2023) Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. Materials Today Bio, 18 (100534). [PMID:36686036] [10.1016/j.mtbio.2022.100534] |
| 3. Haohua Liu, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun. (2022) Formulation of Chrysomycin A Cream for the Treatment of Skin Infections. MOLECULES, 27 (14): (4613). [PMID:35889485] [10.3390/molecules27144613] |
| 4. Li Jun, Liu Xiangmei, Tan Lei, Cui Zhenduo, Yang Xianjin, Liang Yanqin, Li Zhaoyang, Zhu Shengli, Zheng Yufeng, Yeung Kelvin Wai Kwok, Wang Xianbao, Wu Shuilin. (2019) Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds. Nature Communications, 10 (1): (1-15). [PMID:31582736] [10.1038/s41467-019-12429-6] |
| 1. Yupeng Shi, Mengyang Zhou, Shuo Zhao, Haotian Li, Wenhao Wang, Jingliang Cheng, Lin Jin, Yifei Wang. (2023) Janus amphiphilic nanofiber membranes synergistically drive antibacterial and anti-inflammatory strategies for skin wound healing. MATERIALS & DESIGN, 227 (111778). [PMID:] [10.1016/j.matdes.2023.111778] |
| 2. Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao. (2023) Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. Materials Today Bio, 18 (100534). [PMID:36686036] [10.1016/j.mtbio.2022.100534] |
| 3. Haohua Liu, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun. (2022) Formulation of Chrysomycin A Cream for the Treatment of Skin Infections. MOLECULES, 27 (14): (4613). [PMID:35889485] [10.3390/molecules27144613] |
| 4. Li Jun, Liu Xiangmei, Tan Lei, Cui Zhenduo, Yang Xianjin, Liang Yanqin, Li Zhaoyang, Zhu Shengli, Zheng Yufeng, Yeung Kelvin Wai Kwok, Wang Xianbao, Wu Shuilin. (2019) Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds. Nature Communications, 10 (1): (1-15). [PMID:31582736] [10.1038/s41467-019-12429-6] |
