GW 583340 dihydrochloride - ≥97%(HPLC), high purity , CAS No.1173023-85-2

Item Number

G286712

Grouped product items
SKU	Size	Availability	Price	Qty
G286712-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$152.90
G286712-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$623.90

Potent dual EGFR/ErbB2 inhibitor; orally active

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Basic Description

Synonyms	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
Specifications & Purity	Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms	Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50values are 0.01 and 0.014μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50values are 0.11μM for inhibition of HN5, N87 and BT474 tumor cell lines vs
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™

Names and Identifiers

IUPAC Name	N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine;dihydrochloride
INCHI	InChI=1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H
InChi Key	WIMITXDBYLKRKB-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl
Isomeric SMILES	CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl
PubChem CID	16219404
MeSH Entry Terms	GW 583340;GW-583340;GW583340
Molecular Weight	671.03