| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| E413636-5mg | 5mg | 3 | $64.90 | |
| E413636-10mg | 10mg | 3 | $97.90 | |
| E413636-25mg | 25mg | 3 | $220.90 | |
| E413636-50mg | 50mg | 3 | $403.90 | |
| E413636-100mg | 100mg | 3 | $717.90 |
Topo II Selective Inhibitors | Activators
| Synonyms | Q27254611 | 5,11-dimethyl-6H-pyrido[4,3-b]carbazole;hydrochloride | BS-17160 | NSC71795 hydrochloride | D71154 | 5,11-Dimethyl-6H-pyrido(4,3-b)carbazole hydrochloride | BCP30117 | Ellipticine (hydrochloride) | Ellipticine hydrochloride | AC-35692 | UNII-2 |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor ofDNA topoisomerase IIand forms covalent DNA adducts mediated by its oxidation withcytochromes P450 (CYP)andperoxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity. Targets P450 ; peroxidase ; Topo II |
| ALogP | 4.435 |
|---|---|
| HBD Count | 1 |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504757633 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504757633 |
| IUPAC Name | 5,11-dimethyl-6H-pyrido[4,3-b]carbazole;hydrochloride |
| INCHI | InChI=1S/C17H14N2.ClH/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17;/h3-9,19H,1-2H3;1H |
| InChi Key | VSBNVARERCGCEF-UHFFFAOYSA-N |
| Canonical SMILES | CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl |
| Isomeric SMILES | CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl |
| Alternate CAS | 519-23-3 |
| PubChem CID | 169532 |
| Molecular Weight | 282.77 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2506225 | Certificate of Analysis | Mar 18, 2025 | E413636 |
| C2304829 | Certificate of Analysis | Dec 12, 2024 | E413636 |
| C2304828 | Certificate of Analysis | Dec 12, 2024 | E413636 |
| C2304793 | Certificate of Analysis | Dec 12, 2024 | E413636 |
| C2304787 | Certificate of Analysis | Dec 12, 2024 | E413636 |
| C2304489 | Certificate of Analysis | Dec 12, 2024 | E413636 |
| Signal | Warning |
|---|---|
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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