Efficient selective non peptide CCR1 antagonist (KI = 1 nm of human CCR1). The selectivity for CCR1 is 250 times that of CCR2, CCR5 and CXCR4. Inhibit MIP- α/ CCL3 induced intracellular Ca2 + mobilization. Effectively reduce the disease severity of multi
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of CCR1
Product Description
Product Application BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration. It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).
1.Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B et al.. (2000) Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.. J Biol Chem, 275 (25):(19000-8). [PMID:10748002][10.1021/op500134e]
2.Anders HJ, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, Kretzler M, Strutz F, Mack M, Gröne HJ et al.. (2002) A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation.. J Clin Invest, 109 (2):(251-9). [PMID:11805137][10.1021/op500134e]
G2416212