| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B422618-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $318.90 |
Potent, selective CCR1 antagonist
| Synonyms | 217645-70-0 | BX471 | BX 471 | BX-471 free base | BX-471 | ZK-811752 | [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea | BX-741 | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea | 76K1 |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Efficient selective non peptide CCR1 antagonist (KI = 1 nm of human CCR1). The selectivity for CCR1 is 250 times that of CCR2, CCR5 and CXCR4. Inhibit MIP- α/ CCL3 induced intracellular Ca2 + mobilization. Effectively reduce the disease severity of multi |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | ANTAGONIST |
| Mechanism of action | Antagonist of CCR1 |
| Product Description | Product Application |
| IUPAC Name | [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea |
|---|---|
| INCHI | InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1 |
| InChi Key | XQYASZNUFDVMFH-CQSZACIVSA-N |
| Canonical SMILES | CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F |
| Isomeric SMILES | C[C@@H]1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F |
| PubChem CID | 512282 |
| Molecular Weight | 434.89 |
| Pictogram(s) | GHS09, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H302:Harmful if swallowed H400:Very toxic to aquatic life |
| Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
