AR 231453 - ≥99%, high purity , CAS No.733750-99-7, Agonist of GPR119

Item Number

A275017

Grouped product items
SKU	Size	Availability	Price	Qty
A275017-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
A275017-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$423.90

Potent, selective GPR119 agonist

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Basic Description

Synonyms	SPBio_002876 \| N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl)amine \| N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC 50 = 0.68 nM). Enhances glucose-induced insulin release. Antidiabetic activity. Orally active in vivo .
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GPR119
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
INCHI	InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
InChi Key	DGBKNTVAKIFYNU-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=NOC(=N1)C2CCN(CC2)C3=NC=NC(=C3[N+](=O)[O-])NC4=C(C=C(C=C4)S(=O)(=O)C)F
Isomeric SMILES	CC(C)C1=NOC(=N1)C2CCN(CC2)C3=NC=NC(=C3[N+](=O)[O-])NC4=C(C=C(C=C4)S(=O)(=O)C)F
PubChem CID	24939268
Molecular Weight	505.53

References

1. Kang Y et al.. (2016) A role of CB1R in inducing ?-rhythm coordination between the gustatory and gastrointestinal insula.. Sci Rep, 6 (32529). [PMID:27581068]
2. Panaro BL et al.. (2017) ß-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.. Diabetes, 66 (6): (1626-1635). [PMID:28254842]

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Basic Description