ZK 756326 - ≥99%, high purity , CAS No.874911-96-3, Agonist of CCR8

Item Number

Z274772

Grouped product items
SKU	Size	Availability	Price
Z274772-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$23.90
Z274772-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$91.90
Z274772-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$164.90
Z274772-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$372.90
Z274772-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$670.90
Z274772-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$840.90

Non-peptide CCR8 chemokine receptor agonist

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Basic Description

Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Non-peptide CCR8 chemokine receptor agonist (EC 50 = 245 nM). Demonstrates no agonist activity against CCR3, CXCR3, CXCR4 and CCR5. Desensitizes the receptor against CCL1 stimulation.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of CCR8
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
INCHI	InChI=1S/C21H28N2O3.2ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;;/h1-8,17,24H,9-16,18H2;2*1H
InChi Key	MPACCEKWFGWZHS-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl
Isomeric SMILES	C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl
PubChem CID	56972201
Molecular Weight	356.46

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
B2320521	Certificate of Analysis	Dec 22, 2023	Z274772
B2320581	Certificate of Analysis	Dec 22, 2023	Z274772
B2320636	Certificate of Analysis	Dec 22, 2023	Z274772
B2320660	Certificate of Analysis	Dec 22, 2023	Z274772
B2320665	Certificate of Analysis	Dec 22, 2023	Z274772
B2320666	Certificate of Analysis	Dec 22, 2023	Z274772

References

1. Haskell CA, Horuk R, Liang M, Rosser M, Dunning L, Islam I, Kremer L, Gutiérrez J, Marquez G, Martinez-A C et al.. (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.. Mol Pharmacol, 69 (1): (309-16). [PMID:16221874] [10.1021/op500134e]

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Basic Description