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XEN445 - 98% (HPLC), high purity , CAS No.1515856-92-4
Selective endothelial lipase inhibitor
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective endothelial lipase (EL) inhibitor (IC50= 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioava Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 504772299 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772299 IUPAC Name 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid INCHI InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1 InChi Key NBGRERFNOKZQLO-AWEZNQCLSA-N Canonical SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O Isomeric SMILES C1CN(C[C@H]1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O PubChem CID 72736173 Molecular Weight 366.33
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J2120304