| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| X420994-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $201.90 |
Potent, selective KCNQ channel blocker; blocks M current
| Synonyms | XE 991 dihydrochloride | 122955-13-9 | 122955-42-4 | XE991Dihydrochloride | XE991 Dihydrochloride | 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE | XE991 HCl | 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride | 10,10-bis(pyridin-4-ylmethyl) |
|---|---|
| Specifications & Purity | 10mM in Water |
| Biochemical and Physiological Mechanisms | Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks M current. (IC 50 values are 0.98 μM (M-current), 0.71 μM (KCNQ 2), 0.75 μM (KCNQX 1), >100 μM (Kv1.2) and >43 μM (Kv4.3). Potent pulmonary vasoconstrictor. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| IUPAC Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride |
|---|---|
| INCHI | InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H |
| InChi Key | WOGWMARIFDNZON-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl |
| PubChem CID | 45073462 |
| Molecular Weight | 449.4 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
