Withaferin A - ≥98%(HPLC), high purity , CAS No.5119-48-2

Item Number

W133732

Grouped product items
SKU	Size	Availability	Price	Qty
W133732-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
W133732-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$369.90

Naturally occurring withanolide/steroidal lactone with anticancer properties

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Basic Description

Synonyms	NSC273757 \| NSC-273757 \| WITHAFERIN A [MI] \| NCGC00180796-02_C28H38O6_(4beta,5beta,6beta,22R)-4,27-Dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione \| A1-06845 \| C08841 \| DS-13282 \| SMR004701668 \| Ashwagandha \| NSC-101088 \| Withaferine A \| 5.beta.-
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Naturally occurring withanolide/steroidal lactone with anticancer properties. Demonstrates a number of cellular effects including the covalent binding to annexin II, inhibition of chymotrypsin-like activity, PKC and caspase 3. Causes translocation of cyct
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	(1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one
INCHI	InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
InChi Key	DBRXOUCRJQVYJQ-CKNDUULBSA-N
Canonical SMILES	CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO
Isomeric SMILES	CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO
PubChem CID	265237
Molecular Weight	470.6

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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2 results found

Lot Number	Certificate Type	Date	Item
A1818044	Certificate of Analysis	Jun 08, 2023	W133732
A1818043	Certificate of Analysis	Jun 08, 2023	W133732

References

1. Shiota T et al.. (2022) C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response.. Front Cell Dev Biol, 10 (750829). [PMID:35399536]
2. Cortese M et al.. (2020) Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.. Cell Host Microbe, 28 (6): (853-866.e5). [PMID:33245857]

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Basic Description