Basic Description

Synonyms	[r-[r,R-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione \| Orakay \| vitamin K1, 11 \| 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R,R-(E)))- \| BIDD:GT0793 \| DTXCID003472 \| MFCD00214063 \| SCHEMB
Specifications & Purity	≥98%, sum of Cis-trans
Biochemical and Physiological Mechanisms	Vitamin K1 plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Product Description	Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin. Vitamin K{1} is an important dietary source found in green plants, algae and photosynthetic bacteria. It is used as a vitamin (prothrombogenic) and veterinary antidote for dicoumarol poisoning. It is an essential vitamin for the synthesis of coagulation factors II, VII, IX, and X in the liver.

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488195294
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195294
IUPAC Name	2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
INCHI	InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChi Key	MBWXNTAXLNYFJB-NKFFZRIASA-N
Canonical SMILES	CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
Isomeric SMILES	CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
WGK Germany	2
RTECS	QJ5800000
Alternate CAS	12001-79-5
PubChem CID	5284607
Molecular Weight	450.7
Beilstein	2568820
Reaxy-Rn	2568816

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot Number	Certificate Type	Date	Item
B23241024	Certificate of Analysis	Nov 08, 2024	V104147
B23241028	Certificate of Analysis	Nov 08, 2024	V104147
B23241026	Certificate of Analysis	Nov 08, 2024	V104147
B23241025	Certificate of Analysis	Nov 04, 2024	V104147
B23241027	Certificate of Analysis	Nov 04, 2024	V104147
F2415311	Certificate of Analysis	Mar 30, 2024	V104147
B2221328	Certificate of Analysis	Nov 17, 2023	V104147
B2221357	Certificate of Analysis	Nov 17, 2023	V104147
J2309274	Certificate of Analysis	Oct 12, 2023	V104147
J2309273	Certificate of Analysis	Oct 12, 2023	V104147
J2309272	Certificate of Analysis	Oct 12, 2023	V104147
K1901046	Certificate of Analysis	May 09, 2023	V104147
B2103023	Certificate of Analysis	Dec 12, 2022	V104147
B2103022	Certificate of Analysis	Dec 12, 2022	V104147
H2406009	Certificate of Analysis	Oct 11, 2022	V104147
H2406010	Certificate of Analysis	Oct 11, 2022	V104147
G2315062	Certificate of Analysis	Oct 11, 2022	V104147
B23241023	Certificate of Analysis	Oct 11, 2022	V104147

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Safety and Hazards(GHS)

WGK Germany	2
RTECS	QJ5800000
Reaxy-Rn	2568816
Merck Index	7380

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2. Hongpeng Wang, Ruibin Bai, Danqi Hu, Wenxin Chen, Zhuqian Xiao, Jun Huang, Xiufu Wan, Jian Yang, Xuelan Yu. (2023) Structure analysis and in vitro evaluation of probiotic properties for polysaccharides from Phellinus baumii extracted with phosphotungstic acid assistance. LWT-FOOD SCIENCE AND TECHNOLOGY, 188 (29): (115367). [PMID:24396869] [10.1016/j.lwt.2023.115367]
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4. Bowen Qin, Yijun Yao, Jing Zhang, Lifeng Wang. (2023) Bioavailability of Coix Seed Polyphenols in a MKN28/Caco-2 Continuous Transport Model and Their Lipid-Lowering Effects via Modulating Adipocyte Differentiation of 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (22): (8425–8436). [PMID:37233613] [10.1021/acs.jafc.2c08388]
5. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu. (2023) In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota. Food Bioscience, 53 (102600). [PMID:] [10.1016/j.fbio.2023.102600]
6. Sun Hanyu, Li Pugeng, Kong Qingci, Deng Feilong, Yu Xiaolin. (2023) Zoledronic acid affects the process of Porphyromonas gingivalis infecting oral mucosal epithelial barrier: An in-vivo and in-vitro study. Frontiers in Cellular and Infection Microbiology, 13 [PMID:37056703] [10.3389/fcimb.2023.1104826]
7. Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu. (2023) Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis. Food & Function, 14 (2): (857-873). [PMID:36537246] [10.1039/D2FO03424G]
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9. Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia. (2022) Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation. International Journal of Nanomedicine, [PMID:35027826] [10.2147/IJN.S333496]
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15. Li-na Xu, Xiao-yu Yu, Wan-qing Chen, Song-mei Zhang, Jing Qiu. (2020) Biocorrosion of pure and SLA titanium surfaces in the presence of Porphyromonas gingivalis and its effects on osteoblast behavior. RSC Advances, 10 (14): (8198-8206). [PMID:35497867] [10.1039/D0RA00154F]
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References

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47. Rikke G Nejrup,Martin I Bahl,Louise K Vigsnæs,Christine Heerup,Tine R Licht,Lars I Hellgren. (2015-05-21) Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro.. The British journal of nutrition, 114 ((1)): (63-74). [PMID:25992463]
48. S Peter,G Michel,A Hahn,M Ibrahim,A Lubke-Becker,M Jung,R Einspanier,C Gabler. (2015-06-19) Puerperal influence of bovine uterine health status on the mRNA expression of pro-inflammatory factors.. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66 ((3)): (449-462). [PMID:26084227]
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SKU	Size	Availability	Price
V104147-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
V104147-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$23.90
V104147-5g	5g	6	$90.90
V104147-25g	25g	5	$406.90
V104147-100g	100g	2	$1,462.90

Vitamin K1 - 98%(sum of Cis-trans), high purity , CAS No.84-80-0