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Vitamin K₁ (phytomenadione) - Pharmaceutical grade Ph Eur,BP,USP,FCC, high purity , CAS No.84-80-0

CAS#: 84-80-0
Molecular Weight: 450.7
Beilstein Registry Number: 2568820
EC Number: MFCD00214063
PubChem CID: 5284607

Item Number

V434268

Grouped product items
SKU	Size	Availability	Price
V434268-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$181.90
V434268-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$815.90
V434268-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$5,235.90
V434268-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,664.90
V434268-50g	50g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,300.90

Basic Description

Synonyms	[r-[r,R-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione \| Orakay \| vitamin K1, 11 \| 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R,R-(E)))- \| BIDD:GT0793 \| DTXCID003472 \| MFCD00214063 \| SCHEMB
Specifications & Purity	pharmaceutical grade, PharmPure™, Ph.Eur., BP, USP
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Grade	BP, Ph.Eur., pharmaceutical grade, PharmPure™, USP
Product Description	General Description We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our EMPROVE ® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC ® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines Application Vitamin K1 (phytomenadione) EMPROVE ® Essential is suitable for pharmaceutical applications.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
INCHI	InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChi Key	MBWXNTAXLNYFJB-NKFFZRIASA-N
Canonical SMILES	CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
Isomeric SMILES	CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
WGK Germany	2
RTECS	QJ5800000
Alternate CAS	12001-79-5
PubChem CID	5284607
Molecular Weight	450.7
Beilstein	2568820
Reaxy-Rn	2568816

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Safety and Hazards(GHS)

WGK Germany	2
RTECS	QJ5800000
Reaxy-Rn	2568816
Merck Index	7380

Alternative Products

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hongpeng Wang, Ruibin Bai, Danqi Hu, Wenxin Chen, Zhuqian Xiao, Jun Huang, Xiufu Wan, Jian Yang, Xuelan Yu. (2023) Structure analysis and in vitro evaluation of probiotic properties for polysaccharides from Phellinus baumii extracted with phosphotungstic acid assistance. LWT-FOOD SCIENCE AND TECHNOLOGY, 188 (29): (115367). [PMID:24396869] [10.1016/j.lwt.2023.115367]
2. Qinghua Cao, Xiang Xiao, Chengcheng Tao, Rui Shi, Rui Lv, Ruochen Guo, Xinyi Li, Baiyan Sui, Xin Liu, Jian Liu. (2023) Efficient clearance of periodontitis pathogens by S. gordonii membrane-coated H2O2 self-supplied nanocomposites in a “Jenga” style. Biomaterials Science, [PMID:37439322] [10.1039/D3BM00641G]
3. Bowen Qin, Yijun Yao, Jing Zhang, Lifeng Wang. (2023) Bioavailability of Coix Seed Polyphenols in a MKN28/Caco-2 Continuous Transport Model and Their Lipid-Lowering Effects via Modulating Adipocyte Differentiation of 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (22): (8425–8436). [PMID:37233613] [10.1021/acs.jafc.2c08388]
4. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu. (2023) In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota. Food Bioscience, 53 (102600). [PMID:] [10.1016/j.fbio.2023.102600]
5. Sun Hanyu, Li Pugeng, Kong Qingci, Deng Feilong, Yu Xiaolin. (2023) Zoledronic acid affects the process of Porphyromonas gingivalis infecting oral mucosal epithelial barrier: An in-vivo and in-vitro study. Frontiers in Cellular and Infection Microbiology, 13 [PMID:37056703] [10.3389/fcimb.2023.1104826]
6. Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu. (2023) Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis. Food & Function, 14 (2): (857-873). [PMID:36537246] [10.1039/D2FO03424G]
7. Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia. (2022) Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation. International Journal of Nanomedicine, [PMID:35027826] [10.2147/IJN.S333496]
8. Zhijia Wang, Wen Li, Jihui Lu, Zhihua Yuan, Wenmin Pi, Yaozhi Zhang, Haimin Lei, Wenguang Jing, Penglong Wang. (2023) Revealing the active ingredients of the traditional Chinese medicine decoction by the supramolecular strategies and multitechnologies. JOURNAL OF ETHNOPHARMACOLOGY, 300 (115704). [PMID:36096345] [10.1016/j.jep.2022.115704]
9. Yun-Shan Wei, Kun Feng, Shu-Fang Li, Teng-Gen Hu, Min-Hua Zong, Hong Wu. (2022) Highly-hydrophobic nanofiber mat for efficient colonic delivery of lactoferrin: Preparation, characterization and release mechanism. Innovative Food Science & Emerging Technologies, 78 (103015). [PMID:] [10.1016/j.ifset.2022.103015]
10. Xueting Guan, Yujing Feng, Yunyao Jiang, Yeye Hu, Ji Zhang, Zhengpeng Li, Chao Song, Fu Li, Jincai Hou, Ting Shen, Weicheng Hu. (2022) Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota. FOOD RESEARCH INTERNATIONAL, 155 (111074). [PMID:35400452] [10.1016/j.foodres.2022.111074]
11. Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng. (2022) Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro. Food Science and Human Wellness, 11 (97). [PMID:] [10.1016/j.fshw.2021.07.011]
12. Song Li, Baojie Zhang, Jielun Hu, Yadong Zhong, Yonggan Sun, Shaoping Nie. (2021) Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome. Food Frontiers, 2 (2): (218-231). [PMID:] [10.1002/fft2.82]
13. Li-na Xu, Xiao-yu Yu, Wan-qing Chen, Song-mei Zhang, Jing Qiu. (2020) Biocorrosion of pure and SLA titanium surfaces in the presence of Porphyromonas gingivalis and its effects on osteoblast behavior. RSC Advances, 10 (14): (8198-8206). [PMID:35497867] [10.1039/D0RA00154F]
14. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. (2019) Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. INDUSTRIAL CROPS AND PRODUCTS, 137 (508). [PMID:] [10.1016/j.indcrop.2019.05.055]
15. Benkai Qin, Lei Liu, Yangyang Pan, Yingchun Zhu, Xiaohe Wu, Shiyong Song, Guang Han. (2017) PEGylated Solanesol for Oral Delivery of Coenzyme Q10. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65 (16): (3360–3367). [PMID:28418660] [10.1021/acs.jafc.7b00165]
16. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639]

References

1. Hongpeng Wang, Ruibin Bai, Danqi Hu, Wenxin Chen, Zhuqian Xiao, Jun Huang, Xiufu Wan, Jian Yang, Xuelan Yu. (2023) Structure analysis and in vitro evaluation of probiotic properties for polysaccharides from Phellinus baumii extracted with phosphotungstic acid assistance. LWT-FOOD SCIENCE AND TECHNOLOGY, 188 (29): (115367). [PMID:24396869] [10.1016/j.lwt.2023.115367]
2. Qinghua Cao, Xiang Xiao, Chengcheng Tao, Rui Shi, Rui Lv, Ruochen Guo, Xinyi Li, Baiyan Sui, Xin Liu, Jian Liu. (2023) Efficient clearance of periodontitis pathogens by S. gordonii membrane-coated H2O2 self-supplied nanocomposites in a “Jenga” style. Biomaterials Science, [PMID:37439322] [10.1039/D3BM00641G]
3. Bowen Qin, Yijun Yao, Jing Zhang, Lifeng Wang. (2023) Bioavailability of Coix Seed Polyphenols in a MKN28/Caco-2 Continuous Transport Model and Their Lipid-Lowering Effects via Modulating Adipocyte Differentiation of 3T3-L1 Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (22): (8425–8436). [PMID:37233613] [10.1021/acs.jafc.2c08388]
4. Linlin Gao, Lin Zhang, Huan Liu, Jielun Hu. (2023) In vitro gastrointestinal digestion of whole grain noodles supplemented with soluble dietary fiber and their effects on children fecal microbiota. Food Bioscience, 53 (102600). [PMID:] [10.1016/j.fbio.2023.102600]
5. Sun Hanyu, Li Pugeng, Kong Qingci, Deng Feilong, Yu Xiaolin. (2023) Zoledronic acid affects the process of Porphyromonas gingivalis infecting oral mucosal epithelial barrier: An in-vivo and in-vitro study. Frontiers in Cellular and Infection Microbiology, 13 [PMID:37056703] [10.3389/fcimb.2023.1104826]
6. Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu. (2023) Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis. Food & Function, 14 (2): (857-873). [PMID:36537246] [10.1039/D2FO03424G]
7. Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia. (2022) Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation. International Journal of Nanomedicine, [PMID:35027826] [10.2147/IJN.S333496]
8. Zhijia Wang, Wen Li, Jihui Lu, Zhihua Yuan, Wenmin Pi, Yaozhi Zhang, Haimin Lei, Wenguang Jing, Penglong Wang. (2023) Revealing the active ingredients of the traditional Chinese medicine decoction by the supramolecular strategies and multitechnologies. JOURNAL OF ETHNOPHARMACOLOGY, 300 (115704). [PMID:36096345] [10.1016/j.jep.2022.115704]
9. Yun-Shan Wei, Kun Feng, Shu-Fang Li, Teng-Gen Hu, Min-Hua Zong, Hong Wu. (2022) Highly-hydrophobic nanofiber mat for efficient colonic delivery of lactoferrin: Preparation, characterization and release mechanism. Innovative Food Science & Emerging Technologies, 78 (103015). [PMID:] [10.1016/j.ifset.2022.103015]
10. Xueting Guan, Yujing Feng, Yunyao Jiang, Yeye Hu, Ji Zhang, Zhengpeng Li, Chao Song, Fu Li, Jincai Hou, Ting Shen, Weicheng Hu. (2022) Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota. FOOD RESEARCH INTERNATIONAL, 155 (111074). [PMID:35400452] [10.1016/j.foodres.2022.111074]
11. Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng. (2022) Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro. Food Science and Human Wellness, 11 (97). [PMID:] [10.1016/j.fshw.2021.07.011]
12. Song Li, Baojie Zhang, Jielun Hu, Yadong Zhong, Yonggan Sun, Shaoping Nie. (2021) Utilization of four galactans by Bacteroides thetaiotaomicron A4 based on transcriptome. Food Frontiers, 2 (2): (218-231). [PMID:] [10.1002/fft2.82]
13. Li-na Xu, Xiao-yu Yu, Wan-qing Chen, Song-mei Zhang, Jing Qiu. (2020) Biocorrosion of pure and SLA titanium surfaces in the presence of Porphyromonas gingivalis and its effects on osteoblast behavior. RSC Advances, 10 (14): (8198-8206). [PMID:35497867] [10.1039/D0RA00154F]
14. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. (2019) Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. INDUSTRIAL CROPS AND PRODUCTS, 137 (508). [PMID:] [10.1016/j.indcrop.2019.05.055]
15. Benkai Qin, Lei Liu, Yangyang Pan, Yingchun Zhu, Xiaohe Wu, Shiyong Song, Guang Han. (2017) PEGylated Solanesol for Oral Delivery of Coenzyme Q10. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65 (16): (3360–3367). [PMID:28418660] [10.1021/acs.jafc.7b00165]
16. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639]

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