KPT-185 - ≥98% , CAS No.1333151-73-7

CAS: 1333151-73-7 Cat. No.: K129656 Molecular Weight: 355.31

GRADE & PURITY ≥98%

Synonyms

KPT185 | KPT 185 | (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

KPT-185 is a selective CRM1 inhibitor.

Specifications

Synonyms

KPT185 | KPT 185 | (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1, 2, 4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

KPT 185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferatve properties at submicromolar concentrations (IC50 values:100-500nM), induced apoptosis (average5-fold increase), cell-cycle arrest, and myeloid differentiat

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504771285
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771285
• Canonical Smiles: CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
• IUPAC Name: propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
• InChIKey: NLNGWFLRRRYNIL-PLNGDYQASA-N
• INCHI: 1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-
• Isomeric SMILES: CC(C)OC(=O)/C=C\N1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
• Molecular Weight: 355.31
• Reaxy-Rn: 27858055
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27858055&ln=

Associated Targets(Human)

XPO1 Tclin Exportin-1 (375 Activities)

Discover Target: XPO1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO 71 mg/mL Water Ethanol 71 mg/mL
• Molecular Weight: 355.310 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 355.114 Da
• Monoisotopic Mass: 355.114 Da
• Topological Polar Surface Area: 66.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 485.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1