IQ-1 - ≥95%(HPLC) , CAS No.331001-62-8

CAS: 331001-62-8 Cat. No.: I169621 Molecular Weight: 362.42 EC Number: 808-908-6 PubChem CID: 5721207

GRADE & PURITY ≥95%(HPLC)

Synonyms

CCG-208080 | BS-16587 | 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide | 2-(2-(4-Acetylphenyl)hydrazono)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)acetamide | Acetamide,2-[2-(4-acetylphenyl)diazenyl]-2-(3,4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Q 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

Specifications

Synonyms

CCG-208080 | BS-16587 | 2-[2-(4-Acetylphenyl)diazenyl]-2-(3, 4-dihydro-3, 3-dimethyl-1(2H)-isoquinolinylidene)acetamide | 2-(2-(4-Acetylphenyl)hydrazono)-2-(3, 3-dimethyl-3, 4-dihydroisoquinolin-1-yl)acetamide | Acetamide, 2-[2-(4-acetylphenyl)diazenyl]-2-(3, 4

Specifications & Purity

≥95%(HPLC)

Biochemical and Physiological Mechanisms

IQ-1 enhances β-catenin/CBP interactions and blocks β-catenin/p300 driven transcription, which enables mouse embryonic stem cells (ESCs) to be maintained in an undifferentiated pluripotent state, allowing expansion and self-renewal of mouse ESC population

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%(HPLC)

Names and Identifiers

• Pubchem Sid: 504763953
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504763953
• Canonical Smiles: CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N
• IUPAC Name: (2Z)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
• InChIKey: ALJIEVIJBAJISI-PLRJNAJWSA-N
• INCHI: 1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,24H,12H2,1-3H3,(H2,22,27)/b25-19-
• Isomeric SMILES: CC(=O)C1=CC=C(C=C1)N/N=C(/C2=NC(CC3=CC=CC=C32)(C)C)\C(=O)N
• PubChem CID: 5721207
• Molecular Weight: 362.42

Chemical and Physical Properties

• Solubility: solubility DMSO: 10 mg/mL, clear;Ethanol :7 mg/mL Insoluble in water
• Molecular Weight: 362.400 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 362.174 Da
• Monoisotopic Mass: 362.174 Da
• Topological Polar Surface Area: 96.900 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 645.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1