≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
TED-347 TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction . TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.
Targets
TEAD4⋅Yap1 (Cell-free assay) 5.9 μM(EC50)
In vitro
TED-347 is found to inhibit the protein-protein interaction in a time-dependent manner. TED-347 is shown to functionally disrupt the TEAD·Yap1 interaction in cells and to reduce the viability of patient-derived glioblastoma cell lines.
Cell Research(from reference)
Cell lines：HEK-293 cells, GBM43 cells
Concentrations：0.5 µM, 1.0 µM, 5.0 µM, 10 µM, 25 µM
Incubation Time：48 h
| ALogP | 4.594 |
|---|---|
| Recuento HBD | 1 |
| Enlace rotable | 5 |
| Pubchem Sid | 504773516 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773516 |
| Sonrisas canónicas | C1=CC=C(C(=C1)C(=O)CCl)NC2=CC=CC(=C2)C(F)(F)F |
| IUPAC Name | 2-chloro-1-[2-[3-(trifluoromethyl)anilino]phenyl]ethanone |
| InChIKey | JPVDFGYNLUBCSD-UHFFFAOYSA-N |
| INCHI | 1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2 |
| Isómeros SMILES | C1=CC=C(C(=C1)C(=O)CCl)NC2=CC=CC(=C2)C(F)(F)F |
| PubChem CID | 137796964 |
| Peso molecular | 313.7 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 H2229607 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229609 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229610 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229611 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229612 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229614 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| H2229615 | Certificate of Analysis | Jun 09, 2025 | T414291 |
| L2409156 | Certificate of Analysis | Jun 20, 2022 | T414291 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 69 mg/mL (219.95 mM); Ethanol: 25 mg/mL (79.69 mM); Water: ˂1 mg/mL |
|---|---|
| DMSO (mg/ml) Solubilidad máxima | 69 |
| DMSO (mM) Solubilidad máxima | 219.955371373924 |
| Agua (mg/ml) Solubilidad máxima | ˂1 |
| Peso molecular | 313.700 g/mol |
| XLogP3 | 5.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 313.048 Da |
| Monoisotopic Mass | 313.048 Da |
| Topological Polar Surface Area | 29.100 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 361.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
