MSC 2032964A - Moligand™, ≥98%(HPLC) , Inhibitor of mitogen-activated protein kinase kinase kinase 5, CAS No.1124381-43-6, Inhibitor of mitogen-activated protein kinase kinase kinase 5

CAS: 1124381-43-6 Cat. No.: M287311 Peso molecular: 362.31

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide | AS-74425 | MRF-0000032 | N-[5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]pyridine-3-carboxamide | SCHEMBL2788575 | N-(5-(Cycloprop

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1, 2, 4]triazolo[1, 5-a]pyridin-2-yl)nicotinamide | AS-74425 | MRF-0000032 | N-[5-(cyclopropylamino)-7-(trifluoromethyl)-[1, 2, 4]triazolo[1, 5-a]pyridin-2-yl]pyridine-3-carboxamide | SCHEMBL2788575 | N-(5-(Cycloprop

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Potent and selective ASK1 inhibitor (IC50= 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and bra

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of mitogen-activated protein kinase kinase kinase 5

Pureza

≥98%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: C1CC1NC2=CC(=CC3=NC(=NN23)NC(=O)C4=CN=CC=C4)C(F)(F)F
• IUPAC Name: N-[5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]pyridine-3-carboxamide
• InChIKey: XUKGFHHTSUKORV-UHFFFAOYSA-N
• INCHI: 1S/C16H13F3N6O/c17-16(18,19)10-6-12(21-11-3-4-11)25-13(7-10)22-15(24-25)23-14(26)9-2-1-5-20-8-9/h1-2,5-8,11,21H,3-4H2,(H,23,24,26)
• Isómeros SMILES: C1CC1NC2=CC(=CC3=NC(=NN23)NC(=O)C4=CN=CC=C4)C(F)(F)F
• CAS alternativo: 1124381-43-6
• Peso molecular: 362.31
• Reaxy-Rn: 18991297
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18991297&ln=

Objetivos asociados (humanos)

MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 (2 Activities)

Discover Target: MAP3K5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 7.25, Max Conc. mM: 20; Solvent:ethanol, Max Conc. mg/mL: 3.62, Max Conc. mM: 10 with gentle warming
• Peso molecular: 362.310 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 362.11 Da
• Monoisotopic Mass: 362.11 Da
• Topological Polar Surface Area: 84.200 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 529.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1