LNT 1 - ≥98%(HPLC) , CAS No.824983-91-7

CAS: 824983-91-7 Cat. No.: L288189 Peso molecular: 332.33

GRADE & PURITY ≥98%(HPLC)

Synonyms

1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

1-[(2, 3-Dihydro-1, 4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3, 2-d]pyrimidine-2, 4(1H, 3H)-dione

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Potent flap endonuclease 1 (FEN1) inhibitor (IC50= 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cellsin vitro; induces DNA damage response.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Pureza

≥98%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: C1C(OC2=CC=CC=C2O1)CN3C4=C(C(=O)N(C3=O)O)SC=C4
• IUPAC Name: 1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione
• InChIKey: MXQGCMQXTPTJJT-UHFFFAOYSA-N
• INCHI: 1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2
• Isómeros SMILES: C1C(OC2=CC=CC=C2O1)CN3C4=C(C(=O)N(C3=O)O)SC=C4
• Peso molecular: 332.33
• Reaxy-Rn: 9934373
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9934373&ln=

Objetivos asociados (humanos)

ERCC5 Tchem DNA repair protein complementing XP-G cells (1 Activities)

Discover Target: ERCC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (1 Activities)

Discover Target: FEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

T-24 (2342 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 16.62, Max Conc. mM: 50
• Peso molecular: 332.300 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 332.047 Da
• Monoisotopic Mass: 332.047 Da
• Topological Polar Surface Area: 108.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 504.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1