GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been appr
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Peso molecular
404.300 g/mol
XLogP3
4.700
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Rotatable Bond Count
5
Exact Mass
402.999 Da
Monoisotopic Mass
402.999 Da
Topological Polar Surface Area
93.300 Ų
Heavy Atom Count
24
Formal Charge
0
Complexity
479.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Referencias
1.Fengxin Zheng, Jiale Ke, Shiqin Lin, Wenjie Ye, Zhenkun Wu, Yuexin Xu, Suiqing Mai, Yishuang Chen, Zitao Guo, Huazhong Hu, Shuqin Zhang, Jianxin Pang, Qun Zhang, Zean Zhao. (2024) Discovery of cyanidin-3-O-galactoside as a novel CNT2 inhibitor for the treatment of hyperuricemia. BIOORGANIC CHEMISTRY, [PMID:39753042][10.1016/j.bioorg.2024.108108]
2.Jia-hong Liang, Xiao-lei Yi, Jia-min Gong, Zuo Du. (2024) Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro. TOXICOLOGY IN VITRO, [PMID:38670244][10.1016/j.tiv.2024.105833]
3.Yongmei Li, Fengxin Zheng, Shiqi Zhong, Kunlu Zhao, Hui Liao, Jiacheng Liang, Qiang Zheng, Huicong Wu, Shifan Zhang, Ying Cao, Ting Wu, Jianxin Pang. (2024) Protecting against ferroptosis in hyperuricemic nephropathy: The potential of ferrostatin-1 and its inhibitory effect on URAT1. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:38556118][10.1016/j.ejphar.2024.176528]
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