≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research
In Vitro
K6PC-5 (1-10 μM; 24 h) increases the involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs). K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca 2+ signaling. In addition, K6PC-5 stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase. K6PC-5 (1-10 μM; 24 h) promotes fibroblasts proliferation and collagen synthesis in human fibroblasts. K6PC-5 induces intracellular Ca 2+ concentration ([Ca 2+ ] i ) oscillations in human fibroblasts. K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV-induced infection in EBOV-infected EA.hy926 cells. K6PC-5 significantly reduces the virus titers in supernatants of infected cells and strikingly decreased the amount of VP40 in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Increased the involucrin and loricrin levels in a dose-dependent manner. Cell Proliferation AssayCell Line: Human fibroblasts Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly.
In Vivo
In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intrinsically aged hairless mice (56 weeks old)Dosage: 1% (vehicle (PEG:EtOH = 7:3)) Administration: Topical application; twice daily for 2 weeks Result: Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness.
Form:Solid
IC50& Target:SphK1
| Sonrisas canónicas | CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO |
|---|---|
| IUPAC Name | N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide |
| InChIKey | CGYVFCHCRBGGJG-UHFFFAOYSA-N |
| INCHI | 1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24) |
| Isómeros SMILES | CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO |
| PubChem CID | 11660192 |
| Peso molecular | 343.5 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Solubilidad | DMSO : 100 mg/mL (291.12 mM; Need ultrasonic) |
|---|---|
| Peso molecular | 343.500 g/mol |
| XLogP3 | 4.200 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 16 |
| Exact Mass | 343.272 Da |
| Monoisotopic Mass | 343.272 Da |
| Topological Polar Surface Area | 86.600 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 329.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
