Artículos por tema "Drug discovery"

1. Quinoline vs Isoquinoline: How “Where the Nitrogen Sits” Changes Reactivity and Applications
   posted this at 25 feb 2026

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   In drug discovery, catalysis, and materials chemistry, quinoline and isoquinoline are often treated as “pretty similar N-heteroaromatics.” But in real experiments, the differences most likely to trigger rework often come from one key factor: the position of the ring nitrogen.
2. The Role of 7-Membered Nitrogen Heterocycles in Drug Discovery: Microstate Management, Conformational Bias, and Developability Trade-offs (with Research Selection Navigator and Product Tables 1–3)
   posted this at 19 ene 2026

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   7-membered N-heterocycles—as a structural module—are often used because.
3. Late-Stage Fluorination Toolbox: “Minimally Invasive Upgrades” for Lead Candidates： Four “Fluorine Knobs” → Two major routes (electrophilic vs nucleophilic) → An ¹⁸F-PET tracer branch → Selection navigation & representative product list
   posted this at 18 ene 2026

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   In drug discovery, many molecules end up stuck in the same awkward spot: potency is good, but exposure is insufficient; selectivity looks fine, but metabolism is too fast; in vitro is beautiful, yet in vivo distribution is disappointing. In those moments, you usually don’t want to rebuild the ...
4. Targeted drug discovery: scarce and inefficient, what is the geometry of its effectiveness?
   posted this at 9 jun 2025

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   Although target-based drug discovery is currently the dominant approach to drug discovery and development, the latest comprehensive assessment shows that its results are not as good as they could be. The number of drugs discovered by this approach is relatively small, and their therapeutic ...