Experimental Selection Logic for Carboxylic Acid Preactivation Pathways: Differences and Suitable Use Cases for Classical Mixed Anhydrides, CDI, Sulfonyl Chloride Systems, and the Yamaguchi System

Amide bond formation is often described simply as the “condensation of a carboxylic acid with an amine,” yet the actual experimental outcome depends primarily on what kind of activated intermediate the carboxylic acid is first converted into. Different activated intermediates can differ ...