BEC HCl - ≥98% , CAS No.222638-67-7

CAS: 222638-67-7 Cat. No.: B413875 Peso molecular: 229.49 Número EC: 110-433-8 PubChem CID: 91826515

GRADE & PURITY ≥98%

Synonyms

BCP25043 | BEC HCl | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride | BEC hydrochloride | A900880 | XIA63867 | AC-29891 | AKOS030632996 | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride | S-(2-Boronoethyl)-l-cysteine

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Information

BEC HCl BEC HCl is a slow-binding, and competitive arginase inhibitor with K i of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

Targets

Arginase II ; rat Arginase I 0.31 μM(Ki); <0.6 μM(Ki)

In vitro

BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.

In vivo

In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.

Specifications

Sinónimos

BCP25043 | BEC HCl | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride | BEC hydrochloride | A900880 | XIA63867 | AC-29891 | AKOS030632996 | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride | S-(2-Boronoethyl)-l-cysteine

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

BEC HCl is a slow-binding, and competitive arginase inhibitor with K_i of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Propiedades del producto

• ALogP: -2.415
• Enlace rotable: 6

Nombres e identificadores

• Pubchem Sid: 504772680
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772680
• Sonrisas canónicas: B(CCSCC(C(=O)O)N)(O)O.Cl
• IUPAC Name: (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride
• InChIKey: GHPYJLCQYMAXGG-WCCKRBBISA-N
• INCHI: 1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1
• Isómeros SMILES: B(CCSC[C@@H](C(=O)O)N)(O)O.Cl
• PubChem CID: 91826515
• Peso molecular: 229.49

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 45 mg/mL (196.08 mM); Water: 45 mg/mL (196.08 mM); Ethanol: 45 mg/mL (196.08 mM)
• DMSO (mg/ml) Solubilidad máxima: 45
• DMSO (mM) Solubilidad máxima: 196.0869755
• Agua (mg/ml) Solubilidad máxima: 45
• Agua (mM) Solubilidad máxima: 196.0869755
• Peso molecular: 229.490 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 229.035 Da
• Monoisotopic Mass: 229.035 Da
• Topological Polar Surface Area: 129.000 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 145.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3