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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items Aliskiren Hemifumarate - ≥98% , Renin inhibitor, CAS No.173334-58-2, Renin inhibitor
Synonyms
CHEBI:141362 | SCHEMBL187762 | ALISKIREN HEMIFUMARATE [MI] | AMTURNIDE COMPONENT ALISKIREN HEMIFUMARATE | Aliskiren fumarate (JAN/USAN) | NSC-759185 | RASITRIO COMPONENT ALISKIREN HEMIFUMARATE | CCG-270658 | STL557239 | AKOS015896419 | UNII-C8A0P8G029 | (
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Specifications Sinónimos
CHEBI:141362 | SCHEMBL187762 | ALISKIREN HEMIFUMARATE [MI] | AMTURNIDE COMPONENT ALISKIREN HEMIFUMARATE | Aliskiren fumarate (JAN/USAN) | NSC-759185 | RASITRIO COMPONENT ALISKIREN HEMIFUMARATE | CCG-270658 | STL557239 | AKOS015896419 | UNII-C8A0P8G029 | (
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Potent renin inhibitor (IC50= 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Renin inhibitor
Nombres e identificadores Pubchem Sid 488195878 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195878 Sonrisas canónicas CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O IUPAC Name (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioic acid InChIKey KLRSDBSKUSSCGU-KRQUFFFQSA-N INCHI 1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1 Isómeros SMILES CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=C/C(=O)O)\C(=O)O PubChem CID 6918427 Peso molecular 609.83
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:water, Max Conc. mg/mL: 60.98, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 60.98, Max Conc. mM: 100 Sensibilidad Heat, light sensitive Peso molecular 1219.600 g/mol XLogP3 Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 18 Rotatable Bond Count 40 Exact Mass 1218.8 Da Monoisotopic Mass 1218.8 Da Topological Polar Surface Area 367.000 Ų Heavy Atom Count 86 Formal Charge 0 Complexity 836.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 8 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 1 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 1 Covalently-Bonded Unit Count 3
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