GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
The palmitic acid is a PPAR Delta agonist. It was also shown to inhibit fatty acid oxidation, inhibit DHHC-mediated Palmitoylation, and promote glucose uptake in rat heart cells and the insulin-sensitive Murine fibroblast line A31-IS.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Punto de inflamación (°F)
235.4 °F
Punto de inflamación (°C)
113 °C
Punto de fusión (°C)
52-54°C
Peso molecular
335.320 g/mol
XLogP3
7.800
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
14
Exact Mass
334.151 Da
Monoisotopic Mass
334.151 Da
Topological Polar Surface Area
37.300 Ų
Heavy Atom Count
19
Formal Charge
0
Complexity
207.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Referencias
1.Yun Zhou, Song Yue, Lihua Li, Jiahua Zhang, Lei Chen, Jun Chen. (2024) SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF-κB pathway. CELLULAR SIGNALLING, [PMID:38266744][10.1016/j.cellsig.2024.111064]
2.Fang Liu, Yaru Li, Yao Li, Zheng Wang, Xin Li, Yancheng Liu, Yanjun Zhao. (2024) Triggering multiple modalities of cell death via dual-responsive nanomedicines to address the narrow therapeutic window of β-lapachone. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:39270391][10.1016/j.jcis.2024.09.063]
3.You Xujun, Li Honghan, Li Qixin, Zhang Qing, Cao Yiguo, Fu Wei, Wang Bin. (2025) Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, [PMID:40237800][10.1007/s00210-025-04122-x]
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