U-73343 - ≥98% , CAS No.142878-12-4

CAS: 142878-12-4 Cat. No.: U276451 Molecular Weight: 466.7 EC Number: 634-320-2 PubChem CID: 114825

GRADE & PURITY ≥98%

Synonyms

2,5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-2,5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product description：

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC。

Application：

U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells.

U-73343 has been used in measuring the fluorescence of intracellular Ca2+.

Specifications

Synonyms

2, 5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1, 3, 5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1, 3, 5(10)-TRIEN-17-YL)AMINO)HEXYL)-2, 5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Negative control for phospholipase C (PLC) inhibitor U73122 .

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756725
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756725
• Canonical Smiles: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• IUPAC Name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrolidine-2,5-dione
• InChIKey: CJHWFIUASFBCKN-ZRJUGLEFSA-N
• INCHI: 1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• PubChem CID: 114825
• Molecular Weight: 466.7

Associated Targets(Human)

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARSA Tbio Cerebroside-sulfatase (655 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

Discover Target: MTOR

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SH-SY5Y (11521 Activities)

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HEK293 (82097 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

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Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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hsp60 Chaperonin GroEL (Thermosome, HSP60 family) (16 Activities)

Discover Target: hsp60

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated), Methanol (Slightly)
• Melt Point(°C): 139- 141° C
• Molecular Weight: 466.700 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 466.32 Da
• Monoisotopic Mass: 466.32 Da
• Topological Polar Surface Area: 58.600 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 725.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1