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ROCK2

DescriptionRho-associated protein kinase 2

Gene and Protein Information

Gene ID9475
Uniprot Accession IDs O75116 Q53QZ0 Q53SJ7 Q9UQN5
Ensembl ID ENSP00000317985
Symbol KIAA0619 ROCK-II
FamilyBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Sequence
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp470307ROCK2Rho associated coiled-coil containing protein kinase 29598VGNC:6655OMA, EggNOG
Macaque708444ROCK2Rho associated coiled-coil containing protein kinase 29544Inparanoid, OMA, EggNOG
Mouse19878Rock2Rho-associated coiled-coil containing protein kinase 210090MGI:107926Inparanoid, OMA, EggNOG
Rat25537Rock2Rho-associated coiled-coil containing protein kinase 210116RGD:3590Inparanoid, OMA, EggNOG
Dog482970ROCK2Rho associated coiled-coil containing protein kinase 29615VGNC:49640Inparanoid, OMA, EggNOG
Horse100072339ROCK2Rho associated coiled-coil containing protein kinase 29796VGNC:22497Inparanoid, OMA, EggNOG
Cow282041ROCK2Rho associated coiled-coil containing protein kinase 29913VGNC:34082Inparanoid, OMA, EggNOG
Pig397445ROCK2Rho associated coiled-coil containing protein kinase 29823Inparanoid, OMA, EggNOG
Opossum100032706ROCK2Rho associated coiled-coil containing protein kinase 213616Inparanoid, EggNOG
Anole lizard100562729rock2Rho associated coiled-coil containing protein kinase 228377Inparanoid, OMA, EggNOG
Xenopus100493965rock2Rho-associated, coiled-coil containing protein kinase 28364XB-GENE-959451Inparanoid, OMA
Zebrafish317747rock2arho-associated, coiled-coil containing protein kinase 2a7955ZDB-GENE-030115-3Inparanoid, OMA, EggNOG
C. elegans172088let-502Rho-associated protein kinase let-5026239Inparanoid, OMA

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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