≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
SBI-797812 SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT . SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice。
Targets
NAMPT
In vitro
SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+.
In vivo
Plasma concentrations of SBI-797812 after oral administration are low. Higher plasma levels of SBI-797812 are seen after i.p. dosing. The potency of SBI-797812 against mouse NAMPT is investigated. The apparent affinity (EC50) of SBI-797812 for mouse NAMPT is approximately 8-fold less than for human NAMPT, whereas maximal fold activation by SBI-797812 is comparable between the mouse and human NAMPT. Dosing of mice with SBI-797812 elevates liver NAD+.
Cell Research(from reference)
Cell lines：Human A549 lung carcinoma cells
Concentrations：10 μM
Incubation Time：4 h
| ALogP | 0.702 |
|---|---|
| HBD Count | 2 |
| Rotatable Bond | 5 |
| Pubchem Sid | 488202811 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202811 |
| Canonical Smiles | C1CC2CN(CC1O2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=CC=NC=C4 |
| IUPAC Name | 1-[4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)urea |
| InChIKey | KTSOHNHLOLGQCY-UHFFFAOYSA-N |
| INCHI | 1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24) |
| Isomeric SMILES | C1CC2CN(CC1O2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=CC=NC=C4 |
| PubChem CID | 135222620 |
| Molecular Weight | 402.47 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 D2319066 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319071 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319077 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319131 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319135 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319622 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319654 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319660 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319663 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| D2319689 | Certificate of Analysis | Feb 04, 2026 | S414308 |
| Solubility | Solubility (25°C) In vitro DMSO: 80 mg/mL (198.77 mM); Ethanol: 2.5 mg/mL (6.21 mM); Water: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 80 |
| DMSO(mM) Max Solubility | 198.772579322682 |
| Water(mg / mL) Max Solubility | ＜1 |
| Molecular Weight | 402.500 g/mol |
| XLogP3 | 0.700 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 402.136 Da |
| Monoisotopic Mass | 402.136 Da |
| Topological Polar Surface Area | 109.000 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 627.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
