Ro 32-0432 hydrochloride - ≥99%(HPLC) , CAS No.1781828-85-0

CAS: 1781828-85-0 Cat. No.: R288387 Molecular Weight: 489.01 PubChem CID: 70346044

GRADE & PURITY ≥99%(HPLC)

Synonyms

3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

3-[(8S)-8-[(Dimethylamino)methyl]-6, 7, 8, 9-tetrahydropyrido[1, 2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2, 5-dione hydrochloride

Specifications & Purity

≥99%(HPLC)

Biochemical and Physiological Mechanisms

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC'sα, βΙ, βΙΙ, γandεrespectively. Orally

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%(HPLC)

Names and Identifiers

• Canonical Smiles: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl
• IUPAC Name: 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride
• InChIKey: HSPRASOZRZDELU-LMOVPXPDSA-N
• INCHI: 1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H/t17-;/m0./s1
• Isomeric SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5C[C@H](CCN5C6=CC=CC=C64)CN(C)C.Cl
• PubChem CID: 70346044
• Molecular Weight: 489.01

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 4.89, Max Conc. mM: 10 with gentle warming