Name: NSC697923 - ≥98% , CAS No.343351-67-7
Brand: Aladdin Scientific
SKU: N275218
Availability: InStock

NSC697923 - ≥98% , CAS No.343351-67-7

CAS: 343351-67-7 Cat. No.: N275218 Molecular Weight: 267.26 EC Number: 803-500-4

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NSC697923 - ≥98% CAS No(343351-67-7) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

AM20210010 | Furan,2-[(4-methylphenyl)sulfonyl]-5-nitro- | Q27463656 | EN300-115577 | SCHEMBL15200927 | BS-16607 | HY-13811 | NSC697923 | NSC-697923 | s7142 | D83608 | Furan, 2-[(4-methylphenyl)sulfonyl]-5-nitro- | SW220082-1 | A14068 | 2-Nitro-5-p-toluen

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Product description

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.

Product Application
NSC697923 has been used as an inhibitor in STING-dependent NF-κB (nuclear factor-κB) activation after DNA damage, mediated by TRAF6 (TNF receptor-associated factor 6)

Specifications

Synonyms

AM20210010 | Furan, 2-[(4-methylphenyl)sulfonyl]-5-nitro- | Q27463656 | EN300-115577 | SCHEMBL15200927 | BS-16607 | HY-13811 | NSC697923 | NSC-697923 | s7142 | D83608 | Furan, 2-[(4-methylphenyl)sulfonyl]-5-nitro- | SW220082-1 | A14068 | 2-Nitro-5-p-toluen

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Selective, cell-permeable UBE2N inhibitor. Inhibits E2 complex Ubc13-Uev1A. Inhibits NF-κB activation. Induces nuclear accumulation of p53 and apoptosis. Shows potent cytotoxic effects to neuroblastoma cell lines. Shows antitumor effects in vivo.

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid	504758625
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758625
Canonical Smiles	CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]
IUPAC Name	2-(4-methylphenyl)sulfonyl-5-nitrofuran
InChIKey	GAUHIPWCDXOLCZ-UHFFFAOYSA-N
INCHI	1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]
Molecular Weight	267.26
Reaxy-Rn	26175201
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26175201&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
H2309767	Certificate of Analysis	Dec 12, 2025	N275218
H2309772	Certificate of Analysis	Dec 12, 2025	N275218
H2309775	Certificate of Analysis	Dec 12, 2025	N275218
H2309780	Certificate of Analysis	Dec 12, 2025	N275218
H2309782	Certificate of Analysis	Dec 12, 2025	N275218
K2525177	Certificate of Analysis	Dec 08, 2025	N275218
H2309763	Certificate of Analysis	Oct 29, 2025	N275218
H2309770	Certificate of Analysis	Oct 29, 2025	N275218
H2309774	Certificate of Analysis	Oct 29, 2025	N275218
H2309779	Certificate of Analysis	Oct 29, 2025	N275218
H2309786	Certificate of Analysis	Oct 29, 2025	N275218

Solubility	Soluble in ethanol to 25 mM (with gentle warming) and in DMSO to 100 mM
Sensitivity	light sensitive
Molecular Weight	267.260 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	267.02 Da
Monoisotopic Mass	267.02 Da
Topological Polar Surface Area	101.000 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	402.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

NSC697923 - ≥98% , CAS No.343351-67-7

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Show more ⌵

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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