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· · COA & SDS available for every product · Same-day shipping on in-stock items NBI 35965 hydrochloride - ≥98%(HPLC) , CAS No.1782228-59-4
Synonyms
1782228-59-4 | DTXSID10849508 | (10S)-9-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride | AKOS024457428 | NBI 35965 hydrochloride | (7S)-6-(Cyclopropylmethyl)-2-(2,
Storage
Room temperature,Desiccated
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Room temperature,Desiccated Ships Normal Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
1782228-59-4 | DTXSID10849508 | (10S)-9-(cyclopropylmethyl)-3-(2, 4-dichlorophenyl)-10-ethyl-6-methyl-1, 2, 5, 9-tetrazatricyclo[6.3.1.04, 12]dodeca-2, 4, 6, 8(12)-tetraene;hydrochloride | AKOS024457428 | NBI 35965 hydrochloride | (7S)-6-(Cyclopropylmethyl)-2-(2,
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Kivalues are 4 and > 10000 nM at CRF1and CRF2respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) productionin vitro(pIC50values are 7.1 and 6.9
Storage
Room temperature, Desiccated
Names and Identifiers Canonical Smiles CCC1CN2C3=C(N1CC4CC4)C=C(N=C3C(=N2)C5=C(C=C(C=C5)Cl)Cl)C.Cl IUPAC Name (10S)-9-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride InChIKey LNYUWBPFYXPUIO-RSAXXLAASA-N INCHI 1S/C21H22Cl2N4.ClH/c1-3-15-11-27-21-18(26(15)10-13-4-5-13)8-12(2)24-20(21)19(25-27)16-7-6-14(22)9-17(16)23;/h6-9,13,15H,3-5,10-11H2,1-2H3;1H/t15-;/m0./s1 Isomeric SMILES CC[C@H]1CN2C3=C(N1CC4CC4)C=C(N=C3C(=N2)C5=C(C=C(C=C5)Cl)Cl)C.Cl PubChem CID 71433630 Molecular Weight 437.79
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 43.78, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 43.78, Max Conc. mM: 100 Molecular Weight 437.800 g/mol XLogP3 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3 Rotatable Bond Count 4 Exact Mass 436.099 Da Monoisotopic Mass 436.099 Da Topological Polar Surface Area 34.000 Ų Heavy Atom Count 28 Formal Charge 0 Complexity 544.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
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