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ML 323 - Moligand™, ≥98%(HPLC) , Inhibitor of ubiquitin specific peptidase 1, CAS No.1572414-83-5, Inhibitor of ubiquitin specific peptidase 1

CAS: 1572414-83-5 Cat. No.: M288939 Molecular Weight: 384.48 EC Number: 809-209-9
COA
ML 323 - Moligand™, ≥98%(HPLC) CAS No(1572414-83-5) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
Synonyms
HY-17543 | JDA | NCGC00262306-02 | s7529 | BM166458 | ML 323 | CCG-268461 | SW219291-1 | SCHEMBL15847799 | 5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine | 5-methyl-2-[2-(propan-2-yl)phenyl]-N-{[4-(1H-1,2,3-triazol-1-
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
M288939-5mg
3

$36.90

$55.90
Save $19.00 (33.99%)
10mg
M288939-10mg
3

$65.90

$98.90
Save $33.00 (33.37%)
25mg
M288939-25mg
2

$142.90

$214.90
Save $72.00 (33.50%)
50mg
M288939-50mg
2

$231.90

$347.90
Save $116.00 (33.34%)
100mg
M288939-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

$348.90

$523.90
Save $175.00 (33.40%)
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Specifications Names and Identifiers Documentation Advanced Data Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties References Solution Calculators Reviews
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Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
HY-17543 | JDA | NCGC00262306-02 | s7529 | BM166458 | ML 323 | CCG-268461 | SW219291-1 | SCHEMBL15847799 | 5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine | 5-methyl-2-[2-(propan-2-yl)phenyl]-N-{[4-(1H-1, 2, 3-triazol-1-
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
ML323 induces viral replication in vitro and in vivo. It may act as a potential candidate for the intervention of diseases like rheumatoid arthritis and systemic lupus erythematosus. ML323 is a potent selective inhibitor of the USP1–UAF1 deubiquitinase co
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of ubiquitin specific peptidase 1
Purity
≥98%(HPLC)
Names and Identifiers
Pubchem Sid504771797
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504771797
Canonical SmilesCC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C
IUPAC Name5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
InChIKeyVUIRVWPJNKZOSS-UHFFFAOYSA-N
INCHI1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
Isomeric SMILES CC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C
Molecular Weight 384.48
Reaxy-Rn 27050607
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27050607&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Associated Targets(Human)
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTNR1A Tclin Melatonin receptor 1A (2519 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIP4K2B Tchem Phosphatidylinositol-5-phosphate 4-kinase type-2 beta (392 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIP4K2A Tbio Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (1501 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsome (341 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
J2130545Certificate of AnalysisAug 14, 2024 M288939
J2130546Certificate of AnalysisAug 14, 2024 M288939
J2130547Certificate of AnalysisAug 14, 2024 M288939
J2130548Certificate of AnalysisAug 14, 2024 M288939
J2130549Certificate of AnalysisAug 14, 2024 M288939
Chemical and Physical Properties
SolubilitySolvent:DMSO, Max Conc. mg/mL: 38.45, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.45, Max Conc. mM: 100
Molecular Weight384.500 g/mol
XLogP34.600
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass384.206 Da
Monoisotopic Mass384.206 Da
Topological Polar Surface Area68.500 Ų
Heavy Atom Count29
Formal Charge0
Complexity492.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
References
1. Huang Jun, Zhou Hongxiang, He Liang, Zhong Lin, Zhou Ding, Yin Zongsheng.  (2023)  The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.  Journal of Orthopaedic Surgery and Research,  18  (1): (1-12).  [PMID:36859264] [10.1186/s13018-023-03594-y]
Solution Calculators
Reviews

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