GW6471 - 10mM in DMSO , Antagonist of Peroxisome proliferator-activated receptor-α, CAS No.880635-03-0, Antagonist of Peroxisome proliferator-activated receptor-α

CAS: 880635-03-0 Cat. No.: G426654 Molecular Weight: 619.67 EC Number: 804-305-7

GRADE & PURITY 10mM in DMSO

Synonyms

GTPL3440 | MLS006010816 | NCGC00165799-01 | SCHEMBL15153020 | N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide | Propanamide, N-((2S)-2-(((1Z)-1-methyl-3-ox

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

Specifications

Synonyms

GTPL3440 | MLS006010816 | NCGC00165799-01 | SCHEMBL15153020 | N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1, 3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide | Propanamide, N-((2S)-2-(((1Z)-1-methyl-3-ox

Specifications & Purity

10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Mechanism of action

Antagonist of Peroxisome proliferator-activated receptor-α

Names and Identifiers

• Canonical Smiles: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C
• IUPAC Name: N-[(2S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide
• InChIKey: TYEFSRMOUXWTDN-DYQICHDWSA-N
• INCHI: 1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1
• Isomeric SMILES: CCC(=O)NC[C@H](CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)N/C(=C\C(=O)C4=CC=C(C=C4)C(F)(F)F)/C
• WGK Germany: 3
• Alternate CAS: 436159-64-7
• Molecular Weight: 619.67
• Reaxy-Rn: 31837484
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31837484&ln=

Associated Targets(Human)

PPARA Tclin Peroxisome proliferator-activated receptor alpha (0 Activities)

Discover Target: PPARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Molecular Weight: 619.700 g/mol
• XLogP3: 7.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 14
• Exact Mass: 619.266 Da
• Monoisotopic Mass: 619.266 Da
• Topological Polar Surface Area: 93.500 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 954.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

References

1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu.  (2022)  N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation.  PHARMACOLOGICAL RESEARCH,      [PMID:36244543] [10.1016/j.phrs.2022.106491]

2. Hongyi Xian, Ruobing Bai, Yu Feng, Shiyue Tang, Zhiming Li, Chudan Gao, Kaiwei Li, Boxuan Liang, Yizhou Zhong, Yuji Huang, Hao Li, Yanhong Deng, Xiaohong Yang, Xiyun Huang, Xiaoqing Chen, Xingfen Yang, Zhenlie Huang.  (2025)  Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPARγ activation in zebrafish: A comparative study with polymers and oligomers.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:41187537] [10.1016/j.ecoenv.2025.119337]